Most precision medicine tools currently in use face two significant disadvantages. First, they work primarily with ‘dead’ i.e formalin fixed paraffin embedded, or frozen tissue. As a consequence, any profiling done on a tumor represents a snapshot of how the tumor behaved at a certain point in time. However, tumors, much like all tissue in a human body, are dynamic and respond to the challenges they face to their survival in different ways. Second, they rely on deriving inferences for tumor behavior on these snapshots, such as looking at how much of a few protein markers are expressed, or at nucleic acid (DNA/RNA) expression patterns. The genome and the proteome is unfortunately very complex and subject to so much dynamic regulation, that it is difficult to directly correlate protein and nucleic acid changes to therapy options. Our TumorSimilis systems overcomes these issues by working with living tissue in a manner that captures its’ dynamicity over extended durations and assessing drug responses on living tissue.